Pyrazinamide is an antibacterial agent that is used for the treatment of tuberculosis (TB). TB is an infection of the lungs
that is caused by a bacteria, Mycobacterium tuberculosis. In order to ensure that this bacteria is treated properly, pyrazinamide may be used along with other anti-TB drugs.
HOW should this drug be taken ?
Pyrazinamide is a tablet that is to be taken by mouth. It is not effected by food and may be taken without regard to
mealtimes. The amount you take will be determined by your doctor based on your weight. It is usually taken once a day,
but your doctor may prescribe it to be taken twice per week. It is important to follow the directions on the prescription
label carefully, since missing doses of the drug can allow more resistant bacteria to grow.
Complete the full prescribed course of treatment (or the full course recommended on the labelling of non-prescription
products), even if you feel better earlier. If the drug is stopped too quickly, your infection may return.
Do not take more than is prescribed for you and do not stop taking pyrazinamide unless your doctor tells you to.
What should you do if you FORGET a dose?
Take the missed dose as soon as you remember. If you remember at the time to take the next dose, take only the regularly scheduled dose. Do not double the dose.
What ADVERSE EFFECTS can this drug cause ? What should you do about them?
Pyrazinamide may cause your urine to appear dark yellow or brown. It may occasionally cause loss of appetite, fever,
joint pain or swelling (especially the big toe, ankle or knee), unusual bruising or bleeding, unusual tiredness or weakness
or yellowing of your eyes or skin. If any of these occur, contact your doctor immediately.
Pyrazinamide can also make your skin more sensitive to sunlight so be sure to cover up or where a sunscreen while
outdoors. Avoid the use of sunlamps or tanning beds. A skin rash may also occur. If these occur and are bothersome talk to your pharmacist or doctor.
IT IS IMPORTANT THAT YOU KEEP YOUR DOCTOR AND LABORATORY APPOINTMENTS, SO THAT YOUR PROGRESS CAN BE ASSESSED REGULARLY.
IF YOU ARE EXPERIENCING ANY ADVERSE EFFECTS, PLEASE DISCUSS THEM WITH YOUR HEALTH CARE TEAM.
What other PRECAUTIONS should you follow while using this drug ?
Pyrazinamide is usually taken over a long period of time so it is important to watch for any adverse effects. Visit your doctor regularly and report any changes or concerns promptly.
Pyrazinamide can interact with other medicines such as allopurinol, colchicine, and probenecid. It is important to tell
your pharmacist and doctor about all other medicines that you are taking including non-prescription (over-the-counter) medicines.
It is best to avoid alcohol while you are taking pyrazinamide as your liver may become more sensitive while on this medicine.
Please inform your doctor and pharmacist if you are pregnant or breastfeeding.
How should this medication be STORED?
Keep Pyrazinamide in its original container. Store this in a cool, dry area.
IF YOU HAVE ANY QUESTIONS OR CONCERNS ABOUT THIS MEDICATION, PLEASE DISCUSS THEM WITH YOUR NURSE, PHARMACIST, OR PHYSICIAN.
PLEASE WRITE DOWN YOUR QUESTIONS OR CONCERNS TO ENSURE THEY ARE ADDRESSED
