INFORMATION FOR PATIENTS 

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Important notice to all TGH Clinic patients regarding:

Risk of Drug Interaction betweenSt. John's Wort (hypericum perforatum)& HIV medications

What is St. John's Wort typically used for?

St. John's Wort is an herbal product that is available in natural food stores and pharmacies. It is often used for the treatment of mild depression or low mood.

New information has recently become available regarding a significant interaction between St. John's Wort and Indinavir (Crixivan®).

St. John's Wort has been shown to significantly lowerindinavir (Crixivan) levels by almost 60%. This may reduce the effectiveness of your anti-HIV regimen, and possibly lead to increases in viral load and/or drug resistance.

What effect will St. John's Wort have on other HIV medications?

St. John's Wort may also decrease levels of other HIV drugs, such as: 

Protease Inhibitors

  • Nelfinavir (Viracept® )
  • Amprenavir (Agenerase®)
  • Ritonavir (Norvir® )
  • Saquinavir (Fortovase® /Invirase®)
  • ABT-378 (lopinavir)

Non-Nucleoside Reverse Transcriptase Inhibitors

  • Efavirenz (Sustiva® )
  • Nevirapine (Viramune® )
  • Delavirdine (Rescriptor® )

Therefore, it is recommended to AVOID taking St. John's Wort
while on any of these HIV medications.

What should I do if I am taking St. John's Wort?

Please inform your physician & pharmacist immediately.

If you have any other questions or concerns, please feel free to discuss them with your physician or pharmacist.