At this stage, the CD4 count is between 200-500 cells/mm3. Most individuals are still without symptoms. The skin and oral lesions seen in the early stage
may persist or worsen.
Other symptoms that may occur during this stage include:
- Herpes zoster
- recurrent Herpes simplex lesions
- candidiasis (oral and/or vaginal)
- oral hairy leukoplakia
- various constitutional symptoms previously described.
Bacterial sinusitis, bronchitis, or pneumonia may occur. Strep. pneumoniae, Hemophilus influenzae and Staph. aureus
are bacterial pathogens more frequently seen in this group compared with the general population.
Antiretroviral therapy continues and its effectiveness is monitored by serial viral load and CD4 lymphocyte profile determinations. Individual conditions are treated as necessary.
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