Case #2 - Mr. JS
JS is a 38 year old male, former IDU, HIV+ for 3 years
CD4 300, viral RNA 30,000 copies/mL
Has been stable on methadone DOT x 1 year
Decided he was ready to initiate antiretrovirals, and started on Combivir, nelfinavir 1 week ago
Notes:
This patient has been on a protease-containing regimen, but has not had complete viral suppression.
His physician would like to change him to a more potent regimen that includes a protease inhibitor with better bioavailability, as well as a drug from another antiretroviral class.
Thus, the regimen the physician is proposing is: ddI, d4T, ritonavir, and delavirdine.
What potential interactions might one anticipate with this regimen?