Enzyme Induction Interactions

• Slower onset, resolution of effect

• Depends upon half-life of inducer, as well as enzymes

• Usually see maximum induction effect in ~2 weeks; similar time to resolution when drug inducer is discontinued

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• Enzyme induction interactions do not usually become apparent for a week or more, since the enzyme inducer must first reach steady state, and new drug metabolizing enzymes need to be synthesized

• Similarly, once the inducing agent is removed, the interaction may take a few weeks to resolve (time for the inhibitor to be cleared, and for enzymes to degrade)