Absorption Interactions

• Drug absorption can be affected by:

  • Presence or absence/type of food
  • Gastric acid
  • Formation of unabsorbable complexes
  • Induction of p-glycoprotein

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• The absence or presence of food or certain beverages may significantly affect the bioavailability of a number of medications. Drug-food interactions may occur due to a variety of mechanisms, including alteration of gastric pH, formation of unabsorbable cation complexes, increasing solubility, interference with gut metabolism, or decreasing gastric motility.