Antiretroviral Pharmacodynamics
Notes:
PI’s demonstrate a wide range of plasma concentrations, with some patients achieving plasma levels (Cmin) that are below those desired for optimal efficacy. It is important to try to keep PI levels (Cmin) above a target inhibitory concentration (e.g., IC 50 or IC90). This can be difficult, because even with usual doses of PIs, often the Cmin falls very close to the inhibitory concentration. Therefore, if one is late with taking a dose, or has problems with drug absorption or interactions, PI levels may fall below the IC50, and allow the virus to begin replicating again.
Characterizes the relationship between drug exposure and drug susceptibility of the pathogen.