Slide 73 of 76
Notes:
With concomitant administration of rifabutin & lopinavir/ritonavir:
5-6-fold ? rifabutin + metabolite AUC; rifabutin 150 mg daily had no significant effect on lopinavir/r concentrations. Reduce rifabutin dosage by at least 75% (i.e., max. 150 mg q2d or 3 times/week); monitor for adverse events and further decrease rifabutin dose if necessary.
- Azithromycin 1250 mg once weekly is a suitable alternative to rifabutin for the indication of MAC prophylaxis. Azithromycin does not affect the cytochrome P450 system, and therefore should not affect lopinavir concentrations.
