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Notes:
- The majority of benzodiazepines are substrates of CYP3A4, and hence are susceptible to interactions with CYP3A4 inhibitors.
- Significantly elevated benzodiazepine concentrations may result in prolonged or excessive sedative effects.
- Therefore, a reduced benzodiazepine dose should be used, with further dosage adjustments depending upon efficacy or toxicity.
- An alternative is to use a benzodiazepine which undergoes a different route of metabolism; oxazepam, lorazepam, and temezepam undergo glucuronidation, and may be less susceptible to inhibition interactions.
