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Notes:
Methadone is partly metabolized by CYP3A and glucuronyl transferase. While nelfinavir is a CYP3A inhibitor, it also induces the activity of glucuronyl transferase. In clinical practice, 29-47% ? methadone concentrations have been noted when nelfinavir was given to patients on stable methadone dosages. However, no symptoms of methadone withdrawal were observed in these subjects.
- Hsyu et al., CROI 2000, abstract #87
- Beauverie et al. AIDS 1998;12:2510-1.
Monitor for symptoms of methadone withdrawal; adjustment of methadone dosage may be necessary.
