Slide 60 of 76
Notes:
- Once the potential for a significant interaction has been identified, the clinical significance must be determined.
- The clinical significance of an interaction will depend upon several factors, including:
- the magnitude of change in pharmacokinetic parameters
- the efficacy and toxicity of the affected agent(s).
- As already discussed, achieving and maintaining adequate antiretroviral concentrations may play an important part in successful and durable viral suppression. Since the risk of cross-resistance is high with protease inhibitors and NNRTIs, subtherapeutic drug levels should be avoided, in order to minimize the risk of resistance developing.
- In addition, the risk of drug toxicity may be higher with increased drug concentrations (e.g., ritonavir, indinavir)
