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Hugen PWH, Burger DM, Brinkman K, ter Hofstede HJM, Schuurman R, Koopmans PP, et al. Carbamazepine-indinavir interaction causes antiretroviral therapy failure. Ann Pharmacother 2000;34:465-70.
Report of antiretroviral failure with concomitant CBZ-indinavir therapy. ¯ IDV levels to 4-25% of mean population values. Patient later experienced viral breakthrough.
Kato Y, Fujii T, Mizoguchi N, Takata N, Ueda K, Feldman MD, et al. Potential interaction between ritonavir and carbamazepine. Pharmacother 2000;20:851-4
Addition of ritonavir (200-600 mg per day) to a pediatric patient stabilized on CBZ resulted in 70-85% ? serum CBZ levels. Ritonavir concentrations were not measured.
Berbel GA, Latorre IA, Porta EJ, et al. Protease inhibitor-induced carbamazepine toxicity. Clin Neuropharmacol 2000;23:216-8.
Combination resulted in CBZ-related ataxia. Avoid combination if possible.
