Slide 53 of 76
Notes:
- Achieving adequate drug concentrations is a very significant factor in determining the success or failure of highly active combination antiretroviral therapy.
- In a case series of high-dose saquinavir monotherapy, increases in viral load were apparent when drug therapy was interrupted for as little as 3 days
- Preliminary reports also suggest that adequate protease inhibitor exposure may be an independent factor in long-term virologic response
