Slide 43 of 76
Notes:
Hsu et al. analyzed steady-state PK of PIs in combination with RTV from 9 studies. In each study, at least 2 doses of RTV were investigated for a given PI dose. Results suggest that for a given PI dose, increasing the ritonavir dose will increase PI Cmin, while the PI Cmax remains relatively unchanged. In other words, for dual protease inhibitor combinations involving ritonavir:
- to increase PI Cmin, one should increase the ritonavir dose
- to increase PI Cmax, AUC, one should increase the PI dose
- This additional data provides clinicians with further guidance on how to manipulate dosages of protease inhibitor combinations in order to maximize the pharmacokinetic profile.
