Slide 35 of 76
Notes:
Effects on CYP450 are often consistent within a drug class. However, there are certain exceptions:
- macrolides: clarithromycin and erythromycin are potent CYP inhibitors, but azithromycin does not inhibit or induce CYP450
- anticonvulsants: carbamazepine, phenobarbital, and phenytoin are potent enzyme inducer; however, valproic acid and gabapentin do not affect CYP450
- NNRTIs: delavirdine is a potent enzyme inhibitor, while nevirapine and efavirenz primarily act as enzyme inducers
Also, as previously mentioned, some agents may possess both enzyme inhibiting and enzyme inducing properties.
