Slide 34 of 76
Notes:
NB: Some agents may possess both enzyme inhibiting and enzyme inducing properties
Ritonavir
Inhibits CYP3A4, 2D6, 2C9, 2C19
Induces CYP1A2, glucuronosyl transferase
Nelfinavir
Inhibits CYP3A4
Induces glucuronosyl transferase
Efavirenz
Can inhibit or induce CYP3A4
Therefore, it may be much more difficult to predict metabolic interactions with these agents.
