Slide 29 of 76
Notes:
- Most protease inhibitors and NNRTIs primarily affect CYP3A4.
- On the other hand, ritonavir inhibits many cytochrome P450 isoenzymes including CYP3A, CYP2D6, CYP2C9, CYP2C19 and others.
- Therefore, ritonavir has the potential to interact with many more classes of agents which are metabolized via similar routes.
