Slide 27 of 76
Notes:
- A substrate is any drug that is metabolized by one or more of the P450 enzymes
- Most drugs are primarily metabolized by a single P450 enzyme
- Over 50% of metabolized drugs are substrates for the CYP3A4 enzyme
- All protease inhibitors and NNRTIs are substrates of the cytochrome P450 system.
- More specifically, these agents are substrates of CYP3A4; therefore, their disposition may be affected by the presence of enzyme inducers, particularly those that affect CYP3A4.
- In addition, all protease inhibitors and NNRTIs possess enzyme inhibiting and/or inducing properties, and may thus affect the metabolism of other CYP450 substrates.
- Include chart of exact CYP isozyme breakdown
