Slide 5 of 76
Notes:
- Many antiretroviral agents have narrow therapeutic indices, and maintenance of adequate drug concentrations may be necessary in order to achieve optimal virologic benefit. This is especially concerning given that cross-class resistance among protease inhibitors is common. Patients failing therapy with one protease inhibitor often do not experience sustained benefit from switching to another protease inhibitor, even ones with different in vitro resistance mutations.
- Thus, achieving adequate drug concentrations may be a very significant factor in determining the success or failure of current as well as future highly active combination antiretroviral therapy.
