MEDICAL INFORMATION FOR HEALTH CARE PROFESSIONALS

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Treatment  / Medication Fact Sheets


FAMCICLOVIR

Other names: Famvir®

WHY is this medication prescribed ?

Famciclovir (fam-CY-clo-veer) is an antiviral agent used to treat infections such as genital herpes. This infection is caused by a virus called herpes simplex virus (HSV). HSV causes small, fluid-filled blisters which break down into ulcers/sores which may be itchy or painful. These blisters contain many infectious HSV particles. Famciclovir helps stop the virus from spreading, reduces the number of painful blisters and also helps them to heal more quickly. If you start taking famciclovir as soon as you feel an infection starting, it may be possible to actually prevent the blisters from developing. It may also be used in the prevention and treatment of a number of other kinds of infections caused by the herpes virus (eg. shingles). Famciclovir is still a relatively new antiviral agent and is not currently approved for use in patients who are immunosuppressed (ie. advanced HIV disease, kidney and bone marrow transplant).

HOW should this drug be taken ?

The dose of famciclovir will depend on whether your doctor has prescribed the medicine for the treatment of shingles or for genital herpes.

The recommended dose used to treat recurrent genital herpes infections is 125 mg (1 x 125mg tablet) twice daily for a period of five days.

The recommended dose of famciclovir used to treat shingles in adults is 500 mg (1 x 500mg tablet) three times daily for a period of seven days.

In both cases, it is important to start taking your medicine as soon as you can for the best effect.

You may take famciclovir with or without food. Swallow each tablet whole with water. Do not chew it. It is important to finish all the tablets you have been given even if you start to feel better.

What should you do if you FORGET a dose ?

If you miss a dose of famciclovir take it as soon as possible, then just carry on with your regular dosing schedule. If you remember your missed dose close to the time for your next dose (ie. within 2 hours), do not double your dose. Continue with your regular dosing schedule.

What ADVERSE EFFECTS can this drug cause? What should you do about them?

Famciclovir is generally well tolerated. Nausea, vomiting, diarrhea, dizziness or headache may occur. If these effects occur and are bothersome, let your doctor or pharmacist know. Call your doctor immediately if you think you have an allergic reaction (ie. rash) to famciclovir.

IT IS IMPORTANT THAT YOU KEEP YOUR REGULAR DOCTOR'S APPOINTMENTS, SO THAT YOUR PROGRESS CAN BE ASSESSED.

What other precautions should you follow while using this drug ?

Let your doctor know if you have had an allergic reaction or serious side effect to other related antiviral agents such as acyclovir, valacyclovir or ganciclovir.

Famciclovir may interact with other drugs. It is important to let your doctor or pharmacist know about other drugs you are taking, even medications which you can buy without a prescription. It is especially important to let them know if you are taking probenecid (Benemid), cimetidine (Tagamet), steroids (eg. Prednisone) or any anti-cancer drugs before starting famciclovir.

Since famciclovir is removed from the body by your kidneys, it is important to inform your doctor if you have a history of kidney disease prior to taking this medicine. Also tell your doctor if you have HIV, AIDS, or any kind of bone marrow disease.

The safety of famciclovir has not been established during pregnancy or breast feeding. Please discuss this with your doctor or pharmacist if this is a concern.

How should this medication be STORED?

Famciclovir should be stored at room temperature (15-30° C) in a dry place and protected from light. Do not store in the bathroom, as heat and moisture may cause the medication to lose its effectiveness. Keep this drug safely away from children.

IF YOU HAVE ANY QUESTIONS OR CONCERNS ABOUT THIS MEDICATION, PLEASE DISCUSS THEM WITH YOU PHARMACIST, NURSE, OR DOCTOR.

PLEASE WRITE DOWN YOUR QUESTIONS OR CONCERNS TO ENSURE THEY ARE ADDRESSED.

A pharmacist at ___________________ is available to answer questions.

The telephone number is ___________.  Please ask for ____________________.

Adapted from Famvir®Product Monograph 1996; Micromedex, 1996. Edited by the CSHP Ontario Branch Professional Specialty Group in HIV Disease, in conjunction with the HIV/AIDS Outpatient Network of Ontario Coordinators Sub-Group, 1997.