MEDICAL INFORMATION FOR HEALTH CARE PROFESSIONALS

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CLOFAZIMINE

Other names: Lamprene®

WHY is this medication prescribed ?

Clofazimine is an anti-infective medication used for the treatment of Mycobacterium avium complex (MAC) infection. It may also be used to treat a number of other conditions.

HOW should this drug be taken ?

Your dosage is _____________. Clofazimine should be taken with food. You should drink a full glass of water with each dose of clofazimine. What should you do if you FORGET a dose ?

Take the missed dose as soon as you remember. If you remember your missed dose close to the time of your next dose, do not double your dose, just continue with your regular dosing schedule.

What ADVERSE EFFECTS can this drug cause? What should you do about them.

Clofazimine may cause pink or red to brownish-black skin discolouration within a few weeks after starting the medication. If this becomes bothersome to you, check with your doctor.

Discolouration of feces, lining of the eyelids, sputum, sweat, tears and urine commonly occurs. Usually, this side effect does not require medical attention. However, if you wear contact lenses, you might consider wearing glasses instead to prevent discolouration of your contact lenses.

Nausea, vomiting, bloody or black tarry stools or abdominal pain occur rarely. If these effects do happen, you should check with your doctor immediately.

IF YOU ARE EXPERIENCING ANY ADVERSE EFFECTS, PLEASE DISCUSS THEM WITH YOUR HEALTH CARE TEAM.

What other PRECAUTIONS should you follow while using this drug?

As this medication may cause some people to become dizzy, drowsy or less alert than normal, you should make sure you know how you react to this medicine before you drive, use machinery or do anything else that could be dangerous if you are dizzy or are not alert.

Clofazimine can make your skin more sensitive to sunlight or sunlamps than usual. Therefore, wear protective clothing and use a sunscreen with at least an SPF of 15 whenever you are exposed to the sun or sunlamps for prolonged periods. Ask your pharmacist to help you select a sunscreen which protects against drug-sun reactions.

How should this medication be STORED ?

Clofazimine should be stored in a cool (15-30°C) dry place, protected from light and well out of the reach of children.

Do not store in your bathroom as heat and moisture may cause the medication to lose potency.

IF YOU HAVE ANY QUESTIONS OR CONCERNS ABOUT THIS MEDICATION, PLEASE DISCUSS THEM WITH YOUR PHARMACIST, NURSE, OR PHYSICIAN.

PLEASE WRITE DOWN YOUR QUESTIONS OR CONCERNS TO ENSURE THEY ARE ADDRESSED.

A pharmacist at ___________________ is available to answer questions.

The telephone number is ___________.  Please ask for ____________________.

Adapted from the Medication Teaching Manual, 5th edition, copyright 1991, American Society of Hospital Pharmacists. Edited by the CSHP Ontario Branch Professional Specialty Group in HIV Disease, in conjunction with the HIV/AIDS Outpatient Network of Ontario Coordinators Sub-Group, 1996.